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Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
Singh S, Gaur A, Sharma RK, Kumari R, Prakash S, Kumari S, Chaudhary AD, Prasun P, Pant P, Hunkler H, Thum T, Jagavelu K, Bharati P, Hanif K, Chitkara P, Kumar S, Mitra K, Gupta SK. Singh S, et al. Basic Res Cardiol. 2023 Nov 3;118(1):46. doi: 10.1007/s00395-023-01016-y. Basic Res Cardiol. 2023. PMID: 37923788
Here, we aim to explore the cardiac functions of MSI2. We confirmed the presence of MSI2 in the adult mouse, rat heart, and neonatal rat cardiomyocytes. Furthermore, Msi2 was significantly enriched in the heart cardiomyocyte fraction. ...
Here, we aim to explore the cardiac functions of MSI2. We confirmed the presence of MSI2 in the adult mouse, rat heart, …
Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors.
Huang RC, Melton PE, Burton MA, Beilin LJ, Clarke-Harris R, Cook E, Godfrey KM, Burdge GC, Mori TA, Anderson D, Rauschert S, Craig JM, Kobor MS, MacIsaac JL, Morin AM, Oddy WH, Pennell CE, Holbrook JD, Lillycrop KA. Huang RC, et al. Epigenetics. 2022 Aug;17(8):819-836. doi: 10.1080/15592294.2021.1876297. Epub 2021 Feb 8. Epigenetics. 2022. PMID: 33550919 Free PMC article.
Adjusting for perinatal factors, methylation of the dmCpGs within MSI2, RAPH1, and SLC25A10 independently predicted BMI, accounting for 24% of variance. ...Overall findings suggest that DNA methylation in MSI2, RAPH1, and SLC25A10 in blood may be robust markers, med …
Adjusting for perinatal factors, methylation of the dmCpGs within MSI2, RAPH1, and SLC25A10 independently predicted BMI, accounting f …
A de novo 3.54 Mb deletion of 17q22-q23.1 associated with hydrocephalus: a case report and review of literature.
Khattab M, Xu F, Li P, Bhandari V. Khattab M, et al. Am J Med Genet A. 2011 Dec;155A(12):3082-6. doi: 10.1002/ajmg.a.34307. Epub 2011 Nov 3. Am J Med Genet A. 2011. PMID: 22052796 Review.
We describe a female newborn with a de novo 3.54 megabase (Mb) deletion of 17q22-q23.1 (chr17:53,072,536-56,612,662, hg18) including genes from MSI2 to BCAS3 detected by oligonucleotide array comparative genomic hybridization (aCGH). ...Postnatal examination found hypotoni …
We describe a female newborn with a de novo 3.54 megabase (Mb) deletion of 17q22-q23.1 (chr17:53,072,536-56,612,662, hg18) including genes f …